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The efficacy of famciclovir in the treatment of uncomplicated herpes zoster was studied in a placebo-controlleddouble-blind trial of 419 immunocompetent adults139 Treatment was begun within 72 hours of the appearance of lesionsand therapy was continued for 7 daysFamciclovir therapy decreased the median time to full crusting by 2 daysThe effects of famciclovir were greater when therapy was initiated within 48 hours of the onset of rasheffects also were more pronounced in patients 50 years of age or olderThere were no overall differences in the duration of pain before healing of rash between the famciclovirtreated and the placebo groupsIn additionthere was no difference in the incidence of postherpetic neuralgia between the treatment groupsAmong patients who developed postherpetic neuralgiahoweverthe median duration of symptoms was shorter in patients treated with famciclovir than in those given placebo63 days and 119 daysrespectively

Famciclovir is the prodrug of penciclovirIt is an orally administered drug and essentially all is converted to the active antiviral compoundpenciclovirPenciclovir has strong inhibitory effects against herpes simplex virus types 1 and 2as well as varicella zosterTyring and coworkers 252 carried out a study of 454 patients with ophthalmic zoster of the trigeminal nerveIn this study patient were randomized to either oral famciclovir 500 mg three times daily or oral aciclovir 800 mg five times a day for 7 daysThe two drugs appeared to demonstrate similar efficacy and famciclovir was well toleratedBecause the drug is cleared in the kidneydosage must be appropriately reduced for patients with reduced renal functionThere are no well-controlled studies in pregnant womenAlthough testicular toxicity was noted in rodentsstudies in normal males did not show a change in sperm count or motilityUrticariahallucinationsand confusion have been reported by patients taking the drug.

Finallyacyclovir-resistant HSV infectionswhich are an increasing problem in the immunocompromised population184,185,259,260 can be treated with foscarnet or cidofovir.

Your age the condition being treated how severe your condition is other medical conditions you have how you react to the first dose.

Famciclovir is an antiviral drug which is active against the Herpes virusesincluding herpes simplex 1 and 2cold sores and genital herpesand varicella-zostershingles and chickenpoxIt belongs to a class of drugs called nucleoside analogs that mimic one of the building blocks of DNAIt stops the spread of herpes virus in the body by preventing the replication of viral DNA that is necessary for viruses to multiplyOther drugs in the same class include acyclovirZoviraxand valacyclovirValtrexFamciclovir is actually aprodrugthat isnot active directly against virusesInsteadfamciclovir is converted to penciclovir in the bodyand it is the penciclovir that is active against the virusesFamciclovir is active against the same viruses as acyclovir but has a longer duration of actionThereforeit can be taken fewer times each dayFamciclovir does not cure or stop the spread of herpes infectionsFamciclovir relieves painburningitchingand tinglingand also heals and prevents sores associated with herpes infectionsFamciclovir was approved for use by the FDA in June 1994.

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