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The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytesAfter discontinuation of latanoprostpigmentation of the iris is likely to be permanentwhile pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patientsPatients who receive treatment should be informed of the possibility of increased pigmentationBeyond 5 years the effects of increased pigmentation are not knownsee Clinical Studies

Results showed that the onset of noticeable increased iris pigmentation occurred within the first year of treatment for the majority of the patients who developed noticeable increased iris pigmentationPatients continued to show signs of increasing iris pigmentation throughout the five years of the studyObservation of increased iris pigmentation did not affect the incidencenatureor severity of adverse eventsother than increased iris pigmentationrecorded in the studyIOP reduction was similar regardless of the development of increased iris pigmentation during the study.

As with any eye dropsto reduce possible systemic absorptionit is recommended that the lachrymal sac be compressed at the medial canthuspunctal occlusionfor one minuteThis should be performed immediately following the instillation of each drop.

Xalatan eye drops are used to treat certain types of glaucoma and other causes of high pressure inside the eye.

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