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Initial20 mg PO qDay May consider gradually increasing dose after several weeks by 20 mg/daynot to exceed 80 mg qDay.

Table 2Altered Appetite and Weight Treatment Emergent Adverse ReactionsIncidence in PMDD Placebo-Controlled Clinical Trials.

It is unknown whether the suicidality risk extends to longer-term usethat isbeyond several monthsHoweverthere is substantial evidence from placebo-controlled maintenance trials in adults with depression that the use of antidepressants can delay the recurrence of depression.

Tell your doctor right away if any of these unlikely but serious side effects occurunusual or severe mental/mood changessuch as agitationunusual high energy/excitementthoughts of suicideeasy bruising/bleedingmuscle weakness/spasmshakinesstremordecreased interest in sexchanges in sexual abilityunusual weight loss.

Based on the mechanism of action of SNRIs and SSRIsincluding SARAFEMand the potential for serotonin syndromecaution is advised when SARAFEM is coadministered with other drugs that may affect the serotonergic neurotransmitter systemssuch as triptanslinezolidan antibiotic which is a reversible non-selective MAOIlithiumtramadolor StJohn’s Wortsee WARNINGS AND PRECAUTIONSThe concomitant use of SARAFEM with SNRIsSSRIsor tryptophan is not recommendedsee DOSAGE AND ADMINISTRATIONCONTRAINDICATIONSWARNINGS AND PRECAUTIONSand DRUG INTERACTIONS

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