The effectiveness of orlistat or sibutramine on countering weight gain induced by antipsychotic drugs has not been studied yet.
Information about Orlistat.
Tell your doctor and pharmacist if you are allergic to orlistat or any other medicationstalk to your doctor if you are taking medications that suppress the immune system such as cyclosporineNeoralSandimmuneIf you are taking cyclosporineNeoralSandimmunetake it 2 hours before or 2 hours after orlistattell your doctor and pharmacist what prescription and nonprescriptionvitaminsnutritional supplementsand herbal products you are taking or plan to takeBe sure to mention any of the followinganticoagulantsblood thinnerssuch as warfarinCoumadinmedications for diabetessuch as glipizideGlucotrolglyburideDiaBetaDynaseMicronasemetforminGlucophageand insulinmedications to control blood pressuremedications for thyroid diseaseand any other medications for weight losstell your doctor if you have if you have had an organ transplant or if you have cholestasiscondition in which the flow of bile from the liver is blockedor malabsorption syndromeproblems absorbing foodYour doctor will probably tell you not to take orlistattell your doctor if you have or have ever had an eating disorder such as anorexia nervosa or bulimiadiabeteskidney stonespancreatitisinflammation or swelling of the pancreasor gallbladder or thyroid diseasetell your doctor if you are pregnantplan to become pregnantor are breast-feedingDo not take orlistat if you are pregnant or breast-feeding.
Take the missed dose as soon as you remember it unless it is more than 1 hour since you ate a main mealIf it is longer than 1 hour since you ate a main mealskip the missed dose and continue on your regular dosing scheduleDo not take a double dose to make up for a missed one.
The dose-response relationship for orlistat in human volunteers is shown in Figure 1The effect is the percentage of ingested fat excretedreferred to as fecal fat excretion percentageBoth individual dataopen circlesand the curve predicted for the population with the maximum-effect modelcontinuous lineare shown in Figure 1.
Patients should be counseled to take XENICAL as directed with meals or up to one hour after a mealPatients should also be advised to take multivitamin supplementation at least two hours before or after the administration of XENICALor at bedtimesee DOSAGE AND ADMINISTRATION
Because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and betacarotenepatients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutritionsee WARNINGS AND PRECAUTIONSThe vitamin supplement should be taken at least 2 hours before or after the administration of XENICALsuch as at bedtime.
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