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The suitability of treatment with cilostazol should be carefully considered alongside other treatment options such as revascularisation.

Pletal is contraindicated in patients with heart failure of any severityCilostazol and several of its metabolites are inhibitors of phosphodiesterase IIISeveral drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III-IV heart failuresee Contraindications4

The total and unbound oral clearancesadjusted for body weightof cilostazol and its metabolites were not significantly different with respect to age50 to 80 yearsor gender.

Cases of thrombocytopenia or leukopenia progressing to agranulocytosis when Pletal was not immediately discontinued have been reportedAgranulocytosis is reversible on discontinuation of PletalMonitor platelets and white blood cell counts periodically.

It is unknown if this medication passes into breast milkConsult your doctor before breast-feeding.

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