In addition, during post-marketing surveillance, cases of alopecia, aggression and psychotic disorder have been reported in patients taking dostinex.
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The mutagenic potential of cabergoline was evaluated and found to be negative in a battery of in vitro testsThese tests included the bacterial mutationAmestest with Salmonella typhimuriumthe gene mutation assay with Schizosaccharomyces pombe P1 and V79 Chinese hamster cellsDNA damage and repair in Saccharomyces cerevisiae D4and chromosomal aberrations in human lymphocytesCabergoline was also negative in the bone marrow micronucleus test in the mouse.
When used to prevent the onset of normal lactationthe dose is 1 mg of cabergoline given as a single dose on the first day after having a baby.
It is not known whether this drug is excreted in human milkBecause many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from cabergolinea decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the importance of the drug to the motherUse of DOSTINEX for the inhibition or suppression of physiologic lactation is not recommendedsee PRECAUTIONS section
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