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Each subsequent course is started after 7 tablet-free days have followed the preceding course.

EE is highly but non-specifically bound to serum albumin2of the drug levels are present unboundDuring absorption and first liver passageEE is metabolized resulting in a reduced absolute and variable oral bioavailabilityUnchanged drug is not excretedEE metabolites are excreted at a urinary to biliary ratio of 4:6with a half-life of about 1 day.

The use of CPA+EE during lactation may lead to a reduction in the volume of milk produced and to a change in its compositionMinute amounts of the active substances are excreted with the milkThese amounts may affect the child particularly in the first 6 weeks postpartumMothers who are breastfeeding should be advised not to take CPA+EE until the nursing mother has weaned her child off breast milk.

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