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For patients receiving MAO inhibitorsType A or Bsee CONTRAINDICATIONSConcomitant therapy with selegiline and carbidopa levodopa may be associated with severe orthostatic hypotension not attributable to carbidopa levodopa alonesee CONTRAINDICATIONS

If you feel light-headeddizzy or faint get up slowly when getting out of bed or standing up.

There have been reports of patients experiencing intense urges to gambleincreased sexual urgesand other intense urgesand the inability to control these urges while taking one or more of the medications that increase central dopaminergic tone and that are generally used for the treatment of Parkinson’s diseaseincluding SINEMETAlthough it is not proven that the medications caused these eventsthese urges were reported to have stopped in some cases when the dose was reduced or the medication was stoppedPrescribers should ask patients about the development of new or increased gambling urgessexual urges or other urges while being treated with SINEMETPatients should inform their physician if they experience new or increased gambling urgesincreased sexual urgesor other intense urges while taking SINEMETPhysicians should consider dose reduction or stopping the medication if a patient develops such urges while taking SINEMETSee PRECAUTIONSImpulse ControlCompulsive Behaviors

For the reasons stated abovepatients and providers are advised to monitor for melanomas frequently and on a regular basis when using SINEMET for any indicationIdeallyperiodic skin examinations should be performed by appropriately qualified individualse.gdermatologists

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