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This medication may rarely cause a very serious condition called neuroleptic malignant syndromeNMSGet medical help right away if you have any of the following symptomsfevermuscle stiffness/pain/tenderness/weaknesssevere tirednesssevere confusionsweatingfast/irregular heartbeatdark urinesigns of kidney problemssuch as change in the amount of urine

Tell your doctor if you are pregnant or plan to become pregnant during treatmentTaking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newbornsuch as withdrawal symptomsbreathing problemsfeeding problemsfussinesstremorsand limp or stiff musclesHoweveryou may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancyIf you become pregnant while taking Clozarildo not stop taking it without your doctor’s advice.

Clozaril exerts anticholinergic activitywhich may produce undesirable effects throughout the bodyCareful supervision is indicated in the presence of prostatic enlargement and narrow-angle glaucomaProbably on account of its anticholinergic propertiesClozaril has been associated with varying degrees of impairment of intestinal peristalsisranging from constipation to intestinal obstructionfaecal impactionparalytic ileusmegacolon and intestinal infarction ischaemiasee section 4.8On rare occasions these cases have been fatalParticular care is necessary in patients who are receiving concomitant medications known to cause constipationespecially those with anticholinergic properties such as some antipsychotic santidepressants and antiparkinsonian treatmentshave a history of colonic disease or a history of lower abdominal surgery as these may exacerbate the situationIt is vital that constipation is recognised and actively treated.

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