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Adultsone tablet at bedtimeMay be taken up to one hour after going to bed when sleep is difficult to achieve.

Rememberkeep this and all other medicines out of the reach of childrennever share your medicines with othersand use this medication only for the indication prescribed.


Promethazine hydrochloride is readily absorbed from the gastrointestinal tractbut undergoes extensive first pass metabolism in the liverWith only 25of the oral dose reaching the systemic circulation unchangedAfter oral therapy therapeutic effects are identifiable at 15-30 minutes and peak plasma concentrations at 2 to 3 hoursEstimates of terminal half-life in blood plasma have been quoted as 4-6 hoursIt is extensively plasma protein boundIt is eliminated mainly as metabolitespredominantly by the faecalvia biliaryroutewith.

Diphenhydramine can pass into breast milk and may harm a nursing babyAntihistamines may also slow breast milk productionAsk a doctor before using this medicine if you are breast-feeding.

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