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Metronidazole is the major component appearing in the plasmawith lesser quantities of metabolites also being presentLess than 20of the circulating metronidazole is bound to plasma proteinsMetronidazole appears in cerebrospinal fluidsalivaand breast milk in concentrations similar to those found in plasmaBactericidal concentrations of metronidazole have also been detected in pus from hepatic abscesses.
Use of oral metronidazole is associated with a disulfiram-like reaction to alcoholincluding abdominal crampsnauseavomitingheadachesand flushingDiscontinue consumption of alcohol or products containing propylene glycol during and for at least three days after therapy with metronidazolesee PRECAUTIONSDRUG INTERACTIONS
Following a single intravenous infusion of 500 mg metronidazolethe mean AUC24 of metronidazole was higher by 114in patients with severeChild-Pugh Chepatic impairmentand by 54and 53in patients with mildChild-Pugh Aand moderateChild-Pugh Bhepatic impairmentrespectivelycompared to healthy control subjectsThere were no significant changes in the AUC24 of hydroxylmetronidazole in these hepatically impaired patientsA reduction in metronidazole dosage by 50is recommended in patients with severeChild-Pugh Chepatic impairmentsee DOSAGE AND ADMINISTRATIONNo dosage adjustment is needed for patients with mild to moderate hepatic impairmentPatients with mild to moderate hepatic impairment should be monitored for metronidazole associated adverse eventssee PRECAUTIONS and DOSAGE AND ADMINISTRATION
This drug may make you dizzyAlcohol or marijuana can make you more dizzyDo not driveuse machineryor do anything that needs alertness until you can do it safelyTalk to your doctor if you are using marijuana.
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