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CrCl 40-80 mL/minNo adjustments necessary CrCl 20-40 mL/min0.5 mg with mealstitrate slowly and monitor CrCl Enter a drug name and repaglinide.

Repaglinide is used together with diet and exercise to treat type 2 diabetesOther diabetes medicines are sometimes used in combination with repaglinide if needed.

In vitro data indicate that repaglinide is metabolised predominantly by CYP2C8but also by CYP3A4Clinical data in healthy volunteers support CYP2C8 as being the most important enzyme involved in repaglinide metabolism with CYP3A4 playing a minor rolebut the relative contribution of CYP3A4 can be increased if CYP2C8 is inhibitedConsequently metabolismand by that clearance of repaglinidemay be altered by substances which influence these cytochrome P-450 enzymes via inhibition or inductionSpecial care should be taken when inhibitors of both CYP2C8 and 3A4 are co-administered simultaneously with repaglinide.

Many drugs can affect your blood sugarmaking it harder to controlExamples include corticosteroidssuch as prednisonepsychiatric medicinessuch as olanzapinefluoroquinolone antibioticssuch as ciprofloxacinamong othersCheck your blood sugar regularly as directed and share the results with your doctorTell your doctor right away if you have symptoms of high or low blood sugarSee also Side Effects sectionYour doctor may need to adjust your diabetes medicationexercise programor diet.

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