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Before initiating glucovance, obtain an estimated glomerular filtration rate egfr .

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Older adults may be more sensitive to the side effects of this drugespecially lactic acidosis or low blood sugar.

Long-term carcinogenicity studies were performed with metformin alone in ratsdosing duration of 104 weeksand micedosing duration of 91 weeksat doses up to and including 900 mg/kg/day and 1500 mg/kg/dayrespectivelyThese doses are both approximately 4 times the MRHD dose of 2000 mg of the metformin component of Glucovance based on body surface area comparisonsNo evidence of carcinogenicity with metformin alone was found in either male or female miceSimilarlythere was no tumorigenic potential observed with metformin alone in male ratsThere washoweveran increased incidence of benign stromal uterine polyps in female rats treated with 900 mg/kg/day of metformin alone.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancyTalk to your doctor about your risk.

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