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Shallaki possesses tiktabittermadhurasweetand kashayaastringentrasatastegunaqualityof Shallaki is rukshadrylaghulightand tikshnavipakapost-digestive effectis katupungentwhereas viryastrength or effectis ushnaThe doshakarma is kapha-pitta shamakaAccording to classicsShallaki has potent vata-kaphahara properties7,8The key constituents of Shallaki are volatile oil4-8acid resin56-65and gum20-36The triterpenoids are the active constituents and are collectively called boswellic acidsThe gum resin of Bserrata usually contains 43boswellic acidswhich contain a combination of six major constituentsmainly 3 acetyl11 ketoboswellic acidsAKBAwhich help to preserve the structural integrity of joint cartilage and maintain a healthy immune mediator cascade at a cellular level9which is active against pain and inflammation by inhibiting leukotriene synthesisSpecificallyit inhibits the activity of the enzyme 5 lipoxygenase through a non-redox reaction in OA10]
A total of 56 patients with signs and symptoms of SandhivataOAirrespective of agesexoccupation etc who attended OPD of Department of Kayachikitsa in IPGT and RA HospitalGujarat Ayurved UniversityJamnagarwere selected for the clinical trialOut of these49 patients could complete the study and 07 patients discontinued the treatment.
The improvement in radiological findings such as joint spacesubarticular sclerosissynovial effusionarticular erosion and osteophytes was due to the anti-inflammatory activity of Bserrata resinIt soothes the joints and also helps treat levels of synovial fluidmaking the entire structure lubricated and easy to rotate or to moveAKBA helps preserve structural integrity of the joint cartilage and maintains a healthy immune mediator cascade at a cellular levelShallaki is mediated through the vascular phenomenonit improves blood supply to joints and restores integrity of vessels obliterated by spasm of internal damage13Decrease in biochemical parametersmainlyCRPserum triglycerides and erythrocyte sedimentation rateESRis due to anti-inflammatory activity.
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