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Orlistat is a reversible inhibitor of gastrointestinal lipasesIt exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipasesThe inactivated enzymes are thus unavailable to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglyceridesAs undigested triglycerides are not absorbedthe resulting caloric deficit may have a positive effect on weight control.

In a multiple-dose studycoadministration of 50 mg cyclosporine twice daily with 120 mg XENICAL three times daily decreased cyclosporine AUC and Cmax by 31and 25respectivelyIn the same studyadministration of 50 mg cyclosporine twice daily three hours after the administration of 120 mg XENICAL three times daily decreased cyclosporine AUC and Cmax by 17and 4respectively.

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This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.

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